Background : High-density lipoproteins exert pleiotropic effects including antiinflammatory, antiapoptotic, and lipopolysaccharide-neutralizing properties. The authors assessed the effects of reconstituted high-density lipoproteins CSL intravenous injection in different models of sepsis.
CSL or saline solution was administrated 2 h after the sepsis. Primary outcome was survival. Secondary outcomes were plasma cell-free DNA and cytokine concentrations, histology, bacterial count, and biodistribution.
In the pneumonia model, fewer bacteria accumulated in liver and lung of the CSL group. In all models, no difference was found for cytokine concentration. Conclusions : CSL infusion improved survival in different experimental mouse models of sepsis.
It reduced inflammation in both plasma and organs and decreased bacterial count. This suggests an opportunity to explore the therapeutic potential of high-density lipoproteins in septic conditions. What This Article Tells Us That Is New : A human injectable formulation of reconstituted high-density lipoprotein, CSL, composed of apolipoprotein A1 and phosphatidylcholines, was tested in three mouse models of sepsis.
When administered soon after the insult causing sepsis, CSL improved survival and reduced lung injury, apparent neutrophil activation, and plasma markers of inflammation, but not cytokine concentrations. Anesthesiology ; 4 We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. To get started with Anesthesiology, we'll need to send you an email. To add an email address to your ASA account please contact us:.
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A Nature Research Journal. Mountains are the water towers of the world, supplying a substantial part of both natural and anthropogenic water demands 12. They are highly sensitive and prone to climate change 34yet their importance and vulnerability have not been quantified at the global scale. Here we present a global water tower index WTIwhich ranks all water towers in terms of their water-supplying role and the downstream dependence of ecosystems and society.
For each water tower, we assess its vulnerability related to water stress, governance, hydropolitical tension and future climatic and socio-economic changes. We conclude that the most important highest WTI water towers are also among the most vulnerable, and that climatic and socio-economic changes will affect them profoundly.
This could negatively impact 1. The data generated to support the findings of this study are available in an online data repository at zenodo. Third party data used in this study are available as follows. Water demand data used in this study are available upon request from Y. Viviroli, D. Mountains of the world, water towers for humanity: typology, mapping, and global significance. Google Scholar. Immerzeel, W. Climate change will affect the Asian water towers.
Science— Climate change and mountain water resources: overview and recommendations for research, management and policy. Earth Syst. Lehner, B. New global hydrography derived from spaceborne elevation data. Eos 8993— A global inventory of mountains for bio-geographical applications.
Hall, D. Pfeffer, W. The Randolph Glacier Inventory: a globally complete inventory of glaciers. Klein Goldewijk, K. The HYDE 3. Xiao, C. A preliminary study of cryosphere service function and value evaluation. Wang, X.These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. The most influential factors in shape control of the nanoparticles are investigated by simply manipulating their growth kinetics.
The presence of tertiary amines or quaternary ammonium hydroxides as catalysts is essential to promote fast crystallization under mild conditions. The novelty of the present approach relies on the large-scale production of organic-capped TiO 2 nanocrystals to which standard processing of colloidal nanocrystals, such as surface ligand exchange, can be applied for the first time. Concentrated colloidal titania dispersions can be prepared for a number of fundamental studies in homogeneous solutions and represent a new source of easily processable oxide material for many technological applications.
In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed. View Author Information. Cite this: J. Article Views Altmetric. Citations Cited By. This article is cited by publications. Barrow, Antonio Tricoli, Daniel E. Chemistry of Materials31 23 The Journal of Physical Chemistry C17 The Journal of Physical Chemistry C16The h -index is an author-level metric that attempts to measure both the productivity and citation impact of the publications of a scientist or scholar.
The h -index correlates with obvious success indicators such as winning the Nobel Prizebeing accepted for research fellowships and holding positions at top universities. The index can also be applied to the productivity and impact of a scholarly journal  as well as a group of scientists, such as a department or university or country. Hirscha physicist at UC San Diegoas a tool for determining theoretical physicists ' relative quality  and is sometimes called the Hirsch index or Hirsch number.
Formally, if f is the function that corresponds to the number of citations for each publication, we compute the h -index as follows: First we order the values of f from the largest to the lowest value. Then, we look for the last position in which f is greater than or equal to the position we call h this position.
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For example, if we have a researcher with 5 publications A, B, C, D, and E with 10, 8, 5, 4, and 3 citations, respectively, the h -index is equal to 4 because the 4th publication has 4 citations and the 5th has only 3. In contrast, if the same publications have 25, 8, 5, 3, and 3 citations, then the index is 3 i. If we have the function f ordered in decreasing order from the largest value to the lowest one, we can compute the h -index as follows:.
The Hirsch index is analogous to the Eddington numberan earlier metric used for evaluating cyclists. The h -index serves as an alternative to more traditional journal impact factor metrics in the evaluation of the impact of the work of a particular researcher. Because only the most highly cited articles contribute to the h -index, its determination is a simpler process. Hirsch has demonstrated that h has high predictive value for whether a scientist has won honors like National Academy membership or the Nobel Prize.
The h -index grows as citations accumulate and thus it depends on the "academic age" of a researcher. The h -index can be manually determined by using citation databases or using automatic tools. Subscription-based databases such as Scopus and the Web of Science provide automated calculators.
From July Google have provided an automatically-calculated h -index and i index within their own Google Scholar profile. Each database is likely to produce a different h for the same scholar, because of different coverage. Scopus has better coverage of conferences, but poor coverage of publications prior to ; Google Scholar has the best coverage of conferences and most journals though not allbut like Scopus has limited coverage of pre publications.
It has been suggested that in order to deal with the sometimes wide variation in h for a single academic measured across the possible citation databases, one should assume false negatives in the databases are more problematic than false positives and take the maximum h measured for an academic.
Little systematic investigation has been done on how the h -index behaves over different institutions, nations, times and academic fields. A value of about 18 could mean a full professorship, 15—20 could mean a fellowship in the American Physical Societyand 45 or higher could mean membership in the United States National Academy of Sciences.Skip to main content.
Aptamers-guided DNA nanomedicine for cancer theranostics. Weihong Tan The Scientist28 8 Patents X Chen and G Zhu. Albumin binding immunomodulatory compositions. All Publications. Science Advances. Under review.
Nanovaccines for cancer immunotherapy. An albumin sandwich enhances in vivo circulation and stability of metabolically labile peptides. Bioconjug Chem. Self-assembled green tea polyphenol-based coordination nanomaterials to improve chemotherapy efficacy by inhibition of carbonyl reductase 1.
Epub May 1. ACS Nano. Epub Mar 7. Advances in the immunotherapy of type I diabetes. Advanced Drug Delivery Review. Fenton-reaction-accelerable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors.
Zhu G, Chen X. Aptamer-based targeted therapy. Publications prior to VCU. Advanced Materials.Oppo a73 network unlock tool
Polymeric nanoparticles with a glutathione-sensitive heterodimeric multifunctional prodrug for in vivo drug monitoring and synergistic cancer therapy. Angewandte Chemie International Edition.
Toxic reactive oxygen species enhanced synergistic combination therapy by self-assembled metal-phenolic network nanoparticles. Evans blue attachment enhances somatostatin receptor subtype-2 imaging and radiotherapy. A paclitaxel prodrug with bifunctional folate and albumin binding moieties for both passive and active targeted cancer therapy. Aligner-mediated cleavage of nucleic acids and its application to isothermal exponential amplification. Chemical Science. Nature Communications.
Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for personalized cancer immunotherapy.
Importance and vulnerability of the world’s water towers
Nature Communications Transformative nanomedicine of an amphiphilic camptothecin prodrug for long circulation and high tumor uptake in cancer therapy. Efficient nanovaccine delivery in cancer immunotherapy.
Bioconjugate Chemistry.These metrics are regularly updated to reflect usage leading up to the last few days.Roblox my creations
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online.
Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. The activity of a common catalyst H 2 PtCl 6 is shown to depend critically on the nature of the solvent.A105f combination
For instance, 2-propanol preferentially reacts with the surface, preventing any ligand attachment. Chlorobenzene is more stable, allowing some ligand attachment, but the H 2 PtCl 6 catalyst also fosters silicon oxidation.
In contrast, UV irradiation on oxide-free surfaces promotes a cleaner and more efficient reaction, leading to ligand attachment without substrate oxidation. In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
Experimental conditions and infrared data for solvent reactions, UV irradiation time and wavelength dependence on different Si substrates, and stability of the ligand after immobilization. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information.
Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society.
For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system.Norway league predictions
View Author Information. Cite this: J. Article Views Altmetric. Citations Supporting Information Available. Cited By. This article is cited by 51 publications. Pujari, Digvijay Gahtory, Elwin X. Vrouwe, Bauke Albada, and Han Zuilhof.Total number of citations: h-index: For complete publication list.
DattaE. Petala, K. Datta, J. Perman, J. Filip and R. European Patent No. Boosting oxygen evolution reaction performance by nickel substituted cobalt-iron oxide nanoparticles embedded over reduced graphene oxide.
Madakannu, I. Patil, B. Kakade, K. Materials Chemistry and Physics, Yogapriya, K. Journal of Nanoscience and Nanotechnology,20 Invited article on Materials Innovation with Nanoarchitectonics. Jayaramulu, D.
Dubal, B. Nagar, V. Ranc, O. Tomanec, M. Petr, K. Datta, R. Zboril, P.
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